Figure 4.

Transcriptional activation of signaling pathways and drug sensitivity. (A) The from signature to drug analysis indicates that cancer cells showing PTEN inactivation are responsive to mitochondrial inhibitors. (B) Genes identified by the from drug to signature module as up-regulated in cells responsive to mitochondrial inhibitors (as e.g. Oligomycin-A at FDR < 0.05) are functionally enriched in the activation of oxidative phosphorylation, respiratory electron transport chain and ATP synthesis pathways.