Table 1. Feature comparison between selected annotation servers. DE prediction stands for free text protein descriptions. Last database update is taken from explicit statements on annotation servers (at time of writing 22/03/18).

Server	GO prediction	DE prediction	>1000 query sequences	Prob. estimate	Open source	Last database update/update schedule
PANNZER2	Yes	Yes	Yes	Yes	Yes	Monthly (synchronised with UniProt)
ARGOT	Yes	No	Yes	No	No	11/2016
PFP	Yes	No	No	yes	No	Unknown
FunFam	Yes	No	No	No	Data can be downloaded	Daily
INGA	Yes	No	No	Yes	No	04/2015
eggNOG	Yes	Keyword	Yes	No	Yes	11/2017
dcGO	Yes	No	Error	Yes	No	06/2016*

An asterisk (*) following the last database update indicates that timestamps for database files were used instead. Timestamps are conservative because the data might be older than the timestamp suggests.