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NO synthesis through the NADPH and tetrahydrobiopterin-dependent oxidation of the amino acid L-arginine to L-citrulline by NO synthases. AL, argininosuccinate lyase; Arg, arginase; AS, argininosuccinate synthetase; BH4, tetrahydrobiopterin; NOS, NO synthases; OTC, ornithine transcarbamylase.
