Table 1.

Contingency table of observed conversion latencies and cerebellar FA-based conversion predictions. The critical FA threshold of FA_crit = 0.352 is the cerebellar mean FA of patients with early RRMS as determined in our previous study (Deppe et al., 2016b). Sensitivity = TP / (TP + FN) = 10/12 = 0.83, Specificity = TN / (TN + FP) = 4/4 = 1.00, χ² = 8.89, p = 0.0029 (TP = true positive, FN = false negative, FP = false positive, TN = true negative).

Observation test	Early conversion (≤24 months)	Late conversion (>24 months)
FA ≤ FAcrit (test positive)	10 (TP)	0 (FP)	Positive: 10
FA > FAcrit (test negative)	2 (FN)	4 (TN)	Negative: 6
	12	4	16