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. 2018 Jul 3;15:194. doi: 10.1186/s12974-018-1228-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Treatment regimen. Schematic representation of the treatment regimens comprising preventive treatment, therapeutic treatment, and treatment termination, using teriflunomide as medication in the drinking water. “Preventive treatment” started prior to development of major histopathological and clinical features and lasted for 150 or 330 days. “Therapeutic treatment” started when the histopathological phenotype of PLPmut mice has already progressed and lasted for 150 days. “Reaction upon treatment termination” was identical as preventive treatment, but treatment was stopped after 75 days, followed by 75 days of survival time lacking treatment. Note non-invasive analysis during treatment allowing longitudinal studies