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. 2018 Jul 3;15:194. doi: 10.1186/s12974-018-1228-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — OCT reveals reduced thinning of the retinal NFL/GCL/IPL composite layer upon preventive and terminated treatments and regenerative thickening upon therapeutic treatment. a Longitudinal analysis of NFL/GCL/IPL thickness of Wt, untreated PLPmut mice, and preventively treated PLPmut mice at 4, 6, and 9 months of age. Note reduced thinning of the retinal NFL/GCL/IPL composite layer. b Longitudinal analysis of NFL/GCL/IPL thickness of Wt, untreated PLPmut mice and PLPmut mice after 75 days of preventive treatment, followed by 75 days without treatment. Mice were investigated at 4, 6, and 9 months of age. Note that improved NFL/GCL/IPL composite layer thickness was preserved even after treatment termination. c Longitudinal analysis of NFL/GCL/IPL thickness of Wt, untreated PLPmut mice, and therapeutically treated PLPmut mice. Mice were investigated at 10, 12, and 15 months of age. Note unexpected “regenerative” thickening of NFL/GCL/IPL composite layer as a reaction upon therapeutic treatment at 12 and 15 months. One-way ANOVA and Tukey’s post hoc tests. *P < 0.05, **P < 0.01, ***P < 0.001. n = 5 mice per group