Table 2.
Outcomes of repeat surgery for persistent or recurrent acromegaly after surgical treatment
| Authors,Ref. Year | Remission Criteria: Normal IGF-I and | Total No. of Patients | No. of Reoperated Patients | No. of Persistent/Recurrent Patients (% of Each) | Remission Rate (%) | Remission Rate Among Resectable Tumors Only (%) | |
|---|---|---|---|---|---|---|---|
| GHn (μg/L) | GHr (μg/L) | ||||||
| Long et al,30 1996 | <2 | <5 | 212 | 16 | 12/1a (75/6) | 5/16 (31) | NR |
| Freda et al,31 1998 | <2 | <2 | 115 | 12 | 2/10 (17/83) | 4/12 (33) | NR |
| Abe and Lüdecke,32 1998 | <2 | <4.5 | 270 | 28 | 26/2 (93/7) | 16/28 (57) | 16/18 (89) |
| Shimon et al,74 2001 | <2 | <2 | 103 | 12 | 12/0 (100/0) | 1/12 (8) | NR |
| Kurosaki et al,28 2003 | <1 | <2.5 | NR | 22 | 18/4 (82/18) | 13/22 (59) | 13/16 (81) |
| Nomikos et al,27 2005 | <1 | <2.5 | 688 | 140 | 98/42 (70/30) | 38/140 (27) | 38/97 (39) |
| Espinosa de los Monteros,37 2009 | <1 | - | NR | 53 | 53/0 (100/0) | 5/53 (9) | NR |
| Yamada et al,23 2010 | <1 | NR | 482 | 53 | NR | 31/53 (58) | NR |
| Alahmadi et al,29 2012 | <1 | <2.5 | 350 | 9 | NR | 4/9 (44) | 4/5 (80) |
| All studies combined | 345 | 221/59 (79/21) | 117/345 (34) | 71/136 (52) | |||
| Combined studies that used Cortina criteria | 277 | 169/46 (79/21) | 91/267 (34) | 55/118 (47) | |||
Abbreviations: GHn, post-OGTT GH nadir; GHr, random fasting GH; NR, not reported.
a
Indication for surgery was visual impairment for 4 tumors, not specified as persistent or recurrent.