Table 2.
Patient demographics, tumour characteristics and biochemical profile of ACTHomas
| ACTH adenomas (n = 34)
|
|||
|---|---|---|---|
| With central HT (n = 6) | Without central HT (n = 28) | P-value (with vs without central HT) | |
| No. female/male (%) | 6/0 (100/0) | 27/1 (96/4) | 1·0 |
| Mean age (years) | 28·8 ± 4·5 | 40·4 ± 2·2 | 0·04 |
| BMI (kg/m2) | 42·7 ± 6·1 (n = 5) | 37·3 ± 2·6 (n = 19) | 0·38 |
| Prevalence of amenorrhoea (n = premenopausal women) | 100% (n = 5) | 78% (n = 18) | 0·54 |
| Maximal tumour diameter (mm) | 5·83 ± 0·95 (n = 6) | 5·81 ± 0·44 (n = 22) | 0·98 |
| Normalized free T4 | 0·83 ± 0·05 (n = 6) | 1·39 ± 0·04 (n = 28) | <0·0001 |
| Normalized TSH | 0·28 ± 0·09 (n = 6) | 0·45 ± 0·07 (n = 28) | 0·28 |
| Normalized UFC | 2·42 ± 0·28 (n = 6) | 5·10 ± 1·59 (n = 23) | 0·40 |
| Normalized salivary cortisol | 3·45 ± 0·67 (n = 5) | 5·01 ± 1·30 (n = 16) | 0·52 |
HT, hypothyroidism; UFC, urinary free cortisol. Bold font indicates statistically significant P values.