Fig. 1.

The role of rs61991156 in regulatory effects of miR-379 on PKM2 expression and cell proliferation in vitro. a Schematic diagram of rs61991156 SNP in miR-379 targeting PKM2 3′UTR. b, c Comparison of cell proliferation of MKN-45 and AGS human GC cell lines treated differently indicated in the figure. d MKN-45 and AGS were treated as it indicated in the figure, the expression of PKM2 and CyclinD1 were detected by western-blot. e Gene reporter assay was performed in MKN-45 cell, pGL-3 vectors containing 3′UTR of different genotype were co-transfected with both miR-379 and control. Data were presented as the mean ± SEM. *Indicated P < 0.05 and **indicated P < 0.01