Table 2.
Summary of odds ratios (95% CI) in the analysis of the relationship between VEGF gene polymorphisms in rs699947 and coronary artery disease susceptibility
| Genetic Model | Overall and Subgroups | N | Test of Association | Test of Heterogeneity | |||
|---|---|---|---|---|---|---|---|
| OR | 95%CI | P –value | P Heterogeneity | I2 (%) | |||
| Overall | 8 | 1.17 | 0.93,1.47 | 0.170 | 0.040 | 52% | |
| HWE (yes) | 7 | 1.10 | 0.83,1.47 | 0.520 | 0.050 | 53% | |
| PB | 3 | 1.38 | 1.19,1.61 | 0.000 | 0.950 | 0% | |
| CC+ AC vs. AA | HB | 5 | 0.99 | 0.65,1.51 | 0.970 | 0.040 | 65% |
| Large sample size | 3 | 1.34 | 1.16,1.56 | 0.000 | 0.340 | 8% | |
| Small sample size | 5 | 1.06 | 0.67,1.68 | 0.800 | 0.040 | 61% | |
| Asians | 5 | 1.11 | 0.79,1.55 | 0.550 | 0.009 | 71% | |
| Caucasians | 3 | 1.21 | 0.89,1.64 | 0.220 | 0.620 | 0% | |
| Overall | 8 | 0.96 | 0.71,1.31 | 0.800 | 0.000 | 75% | |
| HWE (yes) | 7 | 0.90 | 0.63,1.27 | 0.550 | 0.000 | 74% | |
| PB | 3 | 0.98 | 0.53,1.80 | 0.950 | 0.003 | 83% | |
| CC vs. AA+ AC | HB | 5 | 0.87 | 0.66,1.14 | 0.320 | 0.130 | 45 |
| Large sample | 3 | 1.13 | 0.80,1.60 | 0.480 | 0.010 | 78% | |
| Small sample | 5 | 0.80 | 0.47,1.37 | 0.420 | 0.006 | 73% | |
| Asians | 5 | 0.99 | 0.74,1.48 | 0.790 | 0.000 | 79% | |
| Caucasians | 3 | 0.65 | 0.27,1.56 | 0.340 | 0.010 | 78% | |
| Overall | 8 | 1.26 | 1.10,1.45 | 0.001 | 0.210 | 27% | |
| HWE (yes) | 7 | 1.20 | 1.00,1.44 | 0.050 | 0.180 | 32% | |
| PB | 3 | 1.36 | 1.15,1.60 | 0.000 | 0.510 | 0% | |
| AC vs. AA | HB | 5 | 1.05 | 0.81,1.37 | 0.710 | 0.210 | 32% |
| Large sample | 3 | 1.30 | 1.11,1.52 | 0.001 | 0.680 | 0% | |
| Small sample | 5 | 1.16 | 0.88,1.54 | 0.290 | 0.080 | 53% | |
| Asians | 5 | 1.25 | 1.07,1.46 | 0.005 | 0.150 | 41% | |
| Caucasians | 3 | 1.33 | 0.97,1.83 | 0.080 | 0.250 | 29% | |
| Overall | 8 | 1.05 | 0.71,1.55 | 0.810 | 0.001 | 72% | |
| HWE (yes) | 7 | 0.95 | 0.59,1.53 | 0.770 | 0.001 | 72% | |
| PB | 3 | 1.29 | 0.77,2.17 | 0.340 | 0.030 | 72% | |
| CC vs. AA | HB | 5 | 0.95 | 0.57,1.60 | 0.850 | 0.020 | 65% |
| Large sample | 3 | 1.36 | 0.99,1.88 | 0.060 | 0.110 | 54% | |
| Small sample | 5 | 0.82 | 0.39,1.71 | 0.600 | 0.004 | 74% | |
| Asians | 5 | 1.12 | 0.68,1.83 | 0.660 | 0.001 | 79% | |
| Caucasians | 3 | 0.88 | 0.41,1.89 | 0.740 | 0.070 | 62% | |
| Overall | 8 | 1.01 | 0.83,1.23 | 0.930 | 0.000 | 80% | |
| HWE (yes) | 7 | 0.96 | 0.77,1.21 | 0.750 | 0.000 | 77% | |
| PB | 3 | 1.14 | 0.90,1.45 | 0.280 | 0.020 | 73% | |
| C vs. A | HB | 5 | 0.95 | 0.73,1.22 | 0.680 | 0.008 | 71% |
| Large sample | 3 | 1.13 | 0.90,1.43 | 0.290 | 0.005 | 81% | |
| Small sample | 5 | 0.92 | 0.67,1.27 | 0.620 | 0.005 | 73% | |
| Asians | 5 | 1.04 | 0.79,1.37 | 0.790 | 0.000 | 86% | |
| Caucasians | 3 | 0.97 | 0.75,1.26 | 0.820 | 0.180 | 42% | |
Abbreviations: N number of studies; OR odds ratio; CI confidence interval; HB hospital–based; PB population–based; P–Value, P value for association; P Heterogeneity, P value for heterogeneity