Table 4.
Summary of odds ratios (95% CI) in the analysis of the relationship between VEGF gene polymorphisms in rs3025039 and coronary artery disease susceptibility
| Genetic Model | Overall and Subgroups | N | Test of Association | Test of Heterogeneity | |||
|---|---|---|---|---|---|---|---|
| OR | 95%CI | P –value | P Heterogeneity | I2 (%) | |||
| Overall | 8 | 1.26 | 0.89,1.79 | 0.200 | 0.000 | 84% | |
| HWE (yes) | 7 | 1.14 | 0.86,1.50 | 0.360 | 0.020 | 59% | |
| PB | 2 | 1.24 | 0.32,4.77 | 0.750 | 0.000 | 91% | |
| TT + CT vs. CC | HB | 6 | 1.17 | 0.82,1.65 | 0.390 | 0.020 | 63% |
| Large sample size | 2 | 1.55 | 0.67,3.54 | 0.300 | 0.000 | 96% | |
| Small sample size | 6 | 1.15 | 0.76,1.75 | 0.500 | 0.008 | 71% | |
| Asians | 4 | 1.17 | 0.82,1.65 | 0.390 | 0.020 | 63% | |
| Caucasians | 4 | 0.91 | 0.69,1.20 | 0.40 | 0.490 | 0% | |
| Overall | 8 | 1.38 | 0.98,1.93 | 0.060 | 0.950 | 0% | |
| HWE (yes) | 7 | 1.35 | 0.88,2.05 | 0.170 | 0.910 | 0% | |
| PB | 2 | 1.34 | 0.78,2.29 | 0.290 | 0.430 | 0% | |
| TT vs. CC + CT | HB | 6 | 1.40 | 0.91,2.17 | 0.130 | 0.910 | 0% |
| Large sample size | 2 | 1.37 | 0.88,2.14 | 0.170 | 0.790 | 0% | |
| Small sample size | 6 | 1.40 | 0.91,2.17 | 0.130 | 0.910 | 0% | |
| Asians | 4 | 1.45 | 0.99,2.12 | 0.060 | 0.920 | 0% | |
| Caucasians | 4 | 1.14 | 0.55,2.36 | 0.730 | 0.710 | 0% | |
| Overall | 8 | 1.24 | 0.86,1.80 | 0.250 | 0.000 | 84% | |
| HWE (yes) | 7 | 1.11 | 0.84,1.47 | 0.440 | 0.030 | 58% | |
| PB | 2 | 1.27 | 0.33,4.95 | 0.730 | 0.001 | 91% | |
| CT vs. CC | HB | 6 | 1.18 | 0.89,1.56 | 0.250 | 0.040 | 58% |
| Large sample size | 2 | 1.55 | 0.64,3.72 | 0.330 | 0.000 | 96% | |
| Small sample size | 6 | 1.18 | 0.89,1.56 | 0.250 | 0.040 | 58% | |
| Asians | 4 | 1.64 | 1.01,2.69 | 0.050 | 0.000 | 89% | |
| Caucasians | 4 | 0.89 | 0.66,1.19 | 0.410 | 0.640 | 0% | |
| Overall | 8 | 1.55 | 1.10,2.17 | 0.010 | 0.830 | 0% | |
| HWE (yes) | 7 | 1.39 | 0.91,2.13 | 0.120 | 0.820 | 0% | |
| PB | 2 | 1.67 | 0.98,2.85 | 0.060 | 0.260 | 21% | |
| TT vs. CC | HB | 6 | 1.47 | 0.95,2.28 | 0.080 | 0.830 | 0% |
| Large sample size | 2 | 1.61 | 1.03,2.53 | 0.040 | 0.410 | 0% | |
| Small sample size | 6 | 1.47 | 0.95,2.28 | 0.080 | 0.830 | 0% | |
| Asians | 4 | 1.70 | 1.16,2.50 | 0.007 | 0.810 | 0% | |
| Caucasians | 4 | 1.10 | 0.53,2.28 | 0.810 | 0.650 | 0% | |
| Overall | 8 | 1.23 | 0.93,1.62 | 0.140 | 0.000 | 80% | |
| HWE (yes) | 7 | 1.13 | 0.91,1.42 | 0.270 | 0.040 | 54% | |
| PB | 2 | 1.17 | 0.38,3.57 | 0.780 | 0.002 | 90% | |
| T vs. C | HB | 6 | 1.19 | 0.96,1.48 | 0.110 | 0.070 | 51% |
| Large sample size | 2 | 1.43 | 0.76,2.70 | 0.270 | 0.000 | 95% | |
| Small sample size | 6 | 1.19 | 0.96,1.48 | 0.110 | 0.070 | 51% | |
| Asians | 4 | 1.50 | 1.06,2.13 | 0.020 | 0.000 | 85% | |
| Caucasians | 4 | 0.94 | 0.74,1.21 | 0.640 | 0.390 | 0% | |
Abbreviations: N number of studies; OR odds ratio; CI confidence interval; HB hospital–based; PB population–based; P–Value, P value for association; P Heterogeneity, P value for heterogeneity