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. 2018 Jun 20;2018:7047496. doi: 10.1155/2018/7047496

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Copyright © 2018 Rachael Mooney et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bioactive effects of Bcl-2 expression in NSCs in vivo. (a–c) NSC survival after ipsilateral transplantation into glioma-inoculated mice. (a) Representative xenogen images of ffluc-expressing NSCs at select time points. (b) Quantification of xenogen flux in all animals (mean + SEM) shown at select time points. Asterisks indicate statistically significant increases in NSC flux relative to time-matched parental NSCs (p < 0.05). (c) Representative tissue sections showing DsRed.U251 tumor (red) and NSC (green) injection sites 1 day after NSC injections. NSCs are stained for nestin (present in live and dead NSCs), eGFP (expressed only in live NSCs), and active caspase-3 (expressed only in dying NSCs). (d) LC/MS/MS quantification of 5-FC prodrug (black) and 5-FU (gray) active drug present in mice brains implanted with both parental and genetically modified NSCs.