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. 2018 Jul 4;362:k2505. doi: 10.1136/bmj.k2505

Table 1.

Patients with atrial fibrillation: selected baseline characteristics of patients and comorbidities in the QResearch and Clinical Practice Research Datalink (CPRD) cohorts. Values are percentages (numbers) unless stated otherwise

Characteristic QResearch CPRD
Warfarin Dabigatran Rivaroxaban Apixaban Warfarin Dabigatran Rivaroxaban Apixaban
Total no of patients 53 921 4534 13 597 9199 16 664 1003 2950 1402
Median (interquartile range) days of treatment 344 (150-714) 271 (89-627) 265 (97-496) 248 (100-440) 286 (135-589) 214 (87-479) 163 (69-328) 143 (60-295)
Sex:
 Men 55.5 (29 913) 58.0 (2629) 54.4 (7391) 51.8 (4764) 55.7 (9278) 61.5 (617) 54.1 (1596) 54.9 (769)
 Women 44.5 (24 008) 42.0 (1905) 45.6 (6206) 48.2 (4435) 44.3 (7386) 38.5 (386) 45.9 (1354) 45.1 (633)
Mean (SD) age at baseline 74.8 (10.4) 74.7 (10.7) 75.8 (10.9) 76.5 (10.9) 74.8 (10.3) 74.4 (10.8) 75.9 (10.8) 76.6 (10.9)
Comorbidities at baseline:
 Alcohol dependence 2.4 (1285) 3.2 (143) 2.9 (388) 3.1 (286) 2.2 (365) 2.9 (29) 2.8 (83) 3.4 (48)
 Bleeding disorders 0.9 (486) 0.8 (38) 1.0 (136) 1.1 (102) 1.2 (193) 1.0 (10) 1.5 (43) 1.4 (20)
 Cancer (any) 12.1 (6530) 12.5 (567) 13.3 (1806) 13.1 (1205) 12.4 (2073) 11.2 (112) 12.9 (382) 12.8 (179)
 Chronic liver disease or pancreatitis 1.1 (582) 1.4 (62) 1.4 (187) 1.3 (120) 0.9 (155) 1.7 (17) 1.6 (46) 0.9 (13)
 Chronic obstructive pulmonary disease 9.9 (5355) 8.4 (382) 9.7 (1314) 10.0 (920) 9.5 (1586) 9.6 (96) 9.7 (287) 8.1 (114)
 Chronic renal disease 2.8 (1487) 1.0 (45) 1.6 (224) 2.1 (195) 2.9 (483) 1.5 (15) 2.0 (60) 1.9 (27)
 Congestive cardiac failure 14.1 (7595) 11.1 (502) 11.4 (1553) 12.8 (1173) 13.4 (2227) 11.1 (111) 11.0 (324) 14.9 (209)
 Coronary heart disease 25.3 (13 625) 22.0 (997) 22.1 (3005) 24.3 (2234) 25.5 (4251) 23.0 (231) 21.1 (622) 25.1 (352)
 Diabetes 19.0 (10 255) 17.3 (784) 17.9 (2435) 19.3 (1772) 17.9 (2979) 16.7 (167) 18.0 (530) 19.0 (267)
 Dyspepsia 18.0 (9684) 18.0 (817) 18.6 (2523) 19.1 (1759) 26.1 (4355) 25.4 (255) 26.9 (795) 24.8 (348)
 Falls or hip fracture* 7.6 (4124) 7.1 (322) 7.5 (1015) 8.2 (756) 6.0 (992) 4.9 (49) 6.7 (199) 6.6 (92)
 Hip or knee operation* 0.6 (319) 0.9 (40) 1.0 (131) 0.6 (59) 1.5 (246) 1.2 (12) 1.7 (51) 1.8 (25)
 Hypertension 62.2 (33 555) 60.6 (2746) 59.2 (8053) 59.9 (5513) 62.3 (10 383) 59.9 (601) 62.1 (1833) 62.8 (881)
 Ischaemic stroke 18.1 (9752) 22.0 (999) 16.8 (2290) 22.7 (2091) 18.0 (3001) 23.5 (236) 19.7 (582) 28.2 (396)
 Oesophageal varices 0.1 (51) 0.1 (6) 0.1 (11) 0.1 (11) 0.1 (9) NA NA NA
 Peptic ulcer 7.5 (4065) 7.4 (336) 7.1 (971) 8.4 (772) 8.3 (1380) 7.9 (79) 8.8 (260) 9.6 (135)
 Valvular heart disease 12.2 (6553) 9.4 (428) 8.8 (1191) 10.6 (975) 9.8 (1630) 7.2 (72) 6.6 (196) 9.1 (127)
 Venous thromboembolism 6.4 (3450) 3.0 (138) 6.1 (830) 4.2 (384) 7.7 (1280) 5.6 (56) 7.3 (216) 6.0 (84)
Previous bleed:
 Any† 23.8 (12 848) 25.9 (1176) 26.0 (3541) 27.1 (2493) 28.0 (4674) 29.5 (296) 29.5 (869) 29.7 (417)
 Intracranial† 0.8 (435) 1.2 (54) 1.1 (146) 1.6 (143) 1.1 (191) 1.9 (19) 1.4 (41) 2.1 (30)
Haematuria 10.9 (5883) 12.9 (583) 12.2 (1665) 12.1 (1110) 12.1 (2018) 12.0 (120) 12.0 (354) 11.4 (160)
Haemoptysis† 2.6 (1428) 2.3 (106) 2.7 (364) 2.7 (247) 3.6 (599) 3.4 (34) 3.3 (97) 3.2 (45)
Previous gastrointestinal bleed:†
 All 12.6 (6785) 13.6 (615) 13.8 (1878) 14.8 (1360) 15.7 (2610) 16.7 (168) 17.1 (504) 18.3 (256)
 Upper 4.2 (2260) 4.5 (203) 4.7 (640) 5.1 (471) 5.1 (844) 5.1 (51) 6.2 (184) 6.0 (84)
 Lower 9.4 (5067) 10.4 (472) 10.3 (1394) 10.9 (1004) 12.0 (2004) 12.8 (128) 12.9 (381) 14.0 (196)
Other drugs:
 Proton pump inhibitors 43.4 (23 375) 44.1 (2000) 41.1 (5593) 44.1 (4053) 41.4 (6894) 41.3 (414) 42.1 (1243) 42.4 (594)
 Antibiotics‡ 10.1 (5460) 8.7 (396) 7.5 (1015) 6.8 (622) 9.0 (1495) 6.9 (69) 7.8 (231) 5.1 (71)
 Antiplatelet 29.9 (16 135) 23.3 (1055) 19.8 (2694) 17.4 (1602) 40.2 (6705) 39.1 (392) 31.0 (914) 33.5 (469)
 Antidepressants 15.7 (8444) 14.8 (669) 15.4 (2095) 16.8 (1550) 14.5 (2420) 12.9 (129) 17.3 (510) 17.1 (240)
 Anticonvulsants 0.8 (413) 0.4 (20) 0.6 (85) 0.8 (69) 0.8 (126) 0.5 (5) 0.9 (26) 0.9 (12)
 NSAIDs 6.9 (3709) 8.5 (386) 7.3 (994) 5.7 (523) 6.6 (1105) 8.3 (83) 6.6 (195) 6.1 (85)
 Corticosteroids 12.3 (6633) 11.2 (506) 10.7 (1450) 9.9 (914) 10.9 (1824) 8.9 (89) 10.2 (300) 8.6 (120)
 Statins 55.2 (29 763) 53.6 (2428) 51.3 (6972) 54.1 (4975) 53.4 (8904) 52.9 (531) 51.2 (1509) 56.0 (785)
 Hormones (women) 1.5 (370) 2.3 (43) 1.5 (93) 1.3 (57) 2.7 (199) 2.1 (8) 3.0 (40) 2.8 (18)

For information on age distribution, ethnicity, smoking, alcohol consumption, and Townsend quintiles see supplementary table 3.

NA=not applicable, fewer than 5 observations; NSAIDs=non-steroidal anti-inflammatory drugs.

*

Within the last 6 months.

Based on general practice and Hospital Episode Statistics records.

Within the last 6 months before the drug start date.