Table 3. Univariate and Multivariate Analyses.
Univariate |
Multivariate |
|||||||
---|---|---|---|---|---|---|---|---|
Hazard ratio | P value | 95% CI |
Hazard ratio | P value | 95% CI |
|||
Lower | Upper | Lower | Upper | |||||
Age | 0.755 | 0.235 | 0.461 | 1.193 | ||||
Gender | 0.329 | < 0.001 | 0.204 | 0.514 | 0.367 | 0.003 | 0.183 | 0.717 |
Smoking status | 0.349 | < 0.001 | 0.215 | 0.549 | 0.696 | 0.323 | 0.344 | 1.435 |
Histology | 0.250 | < 0.001 | 0.165 | 0.382 | 0.439 | 0.001 | 0.271 | 0.715 |
pT status | 0.450 | < 0.001 | 0.298 | 0.683 | 0.958 | 0.866 | 0.590 | 1.580 |
pN status | 0.330 | < 0.001 | 0.211 | 0.534 | 0.409 | 0.002 | 0.242 | 0.704 |
CEA | 0.382 | < 0.001 | 0.252 | 0.586 | 0.446 | 0.001 | 0.287 | 0.702 |
CYFRA21-1 | 0.353 | < 0.001 | 0.229 | 0.556 | 0.835 | 0.502 | 0.501 | 1.428 |
GPS | 0.409 | < 0.001 | 0.265 | 0.622 | 0.499 | 0.009 | 0.296 | 0.838 |
NLR | 0.309 | 0.003 | 0.168 | 0.635 | 0.963 | 0.922 | 0.472 | 2.139 |
PLR | 0.462 | < 0.001 | 0.306 | 0.698 | 0.834 | 0.532 | 0.471 | 1.473 |
PNI | 0.599 | 0.017 | 0.396 | 0.910 | 0.772 | 0.346 | 0.449 | 1.323 |
SII | 0.368 | < 0.001 | 0.241 | 0.556 | 0.927 | 0.841 | 0.444 | 1.920 |
ALI | 0.312 | < 0.001 | 0.204 | 0.473 | 0.444 | 0.026 | 0.217 | 0.907 |
GPS: Glasgow prognostic score; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; PNI: prognostic nutritional index; SII: systemic immune-inflammation index; ALI: advance lung cancer inflammation index; CEA: carcinoembryonic antigen; CYFRA21-1: cytokeratin 19 fragments; CI: confidence interval.