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. 2018 Mar 21;72(7):564–571. doi: 10.1136/jech-2017-210061

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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Variable importance in projection plots and proportion of variance explained by protein. Results are presented for PLS model (A), for sparse PLS performing variable selection on exposures (B), on proteins (C), and both on exposures and proteins (D). CCL11, C-C motif chemokine 11, CCL2 motif, chemokine (C-C motif) ligand 2; CCL22, C-C motif chemokine 22; CRP, C reactive protein; CXCL10, C-X-C motif chemokine 10; EGF, epidermal growth factor, G-CSF, granulocyte colony-stimulating factor; IL, interleukin; MPO, myeloperoxidase; PLS, partial least squares; sVEGF, vascular endothelial growth factor.