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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Cancer Res. 2018 May 7;78(13):3497–3509. doi: 10.1158/0008-5472.CAN-17-3498

Figure 6. Nuclear IGF-1R is present on promoters of clinical prostate cancers, and correlates with JUN expression.

Figure 6

A. Fresh frozen prostate cancers underwent IGF-1R or control (IgG) ChIP-qPCR for IGF-1R binding regions of JUN and FAM21A promoters. Upper: relative IGF-1R enrichment; center: representative IGF-1R IHC from adjacent FFPE tumor (scale bar 20μm); lower: Gleason grades and IGF-1R scores in membrane (M), cytoplasm (C), nucleus (N). B. IGF-1R and JUN IHC on adjacent RP sections, showing Gleason 4 pattern gland (scale bar 30μm). C. Graph: total JUN immunoreactive scores in n=80 RPs correlated with nuclear IGF-1R (Spearman coefficient). D. Nuclear IGF-1R binds to DNA and interacts with transcriptional regulators, inducing expression of genes that promote tumor cell survival and migration.