Table 1. Nuclear IGF-1R associates with advanced stage prostate cancer.

IGF-1R IHC was performed on 137 radical prostatectomies. Internalized (nuclear plus cytoplasmic) IGF-1R showed borderline association with higher Gleason grade tumors, and nuclear IGF-1R was significantly associated with tumours of higher pathological stage (Chi-square test). There were no significant associations between clinical parameters and total IGF-1R or IGF-1R in the plasma membrane or cytoplasm (Supplementary Table S3).

	Internalized IGF-1R
	IGF-1R ≤ 6	IGF-1R > 6	p-value
Stage
Stage pT1-2	40	27	0.293
Stage pT3	35	34
Grade:
Gleason grade 6 + 7(3+4)	59	39	0.057
Gleason grade 7(4+3) + 8-9	16	22
PSA
0-10	60	43	0.422
> 10	15	15
	Nuclear IGF-1R
	IGF-1R = 0	IGF-1R > 0	p-value
Stage
Stage pT1-2	50	17	0.011
Stage pT3	37	32
Grade:
Gleason grade 6 + 7(3+4)	64	34	0.602
Gleason grade 7(4+3) + 8-9	23	15
PSA
0-10	67	36	0.612
> 10	18	12