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. 2018 Jun 12;11(6):dmm031013. doi: 10.1242/dmm.031013

Fig. 3.

Fig. 3.

Developmental milestones in male Ts1Cje, Ts65Dn and Dp(16)1/Yey neonates. Developmental milestones were measured on a daily basis between birth and P21 in Ts1Cje mice (n=32 trisomic mice, n=64 euploid littermates); Ts65Dn mice (n=34 trisomic mice, n=23 euploid littermates); and Dp(16)1/Yey mice (n=30 trisomic mice, n=72 euploid littermates). Graphs showing day on which criteria were met on each task in trisomic mice compared with euploid littermates. Plots show median value for each group tested, first and third quartiles, data range and outliers; *P<0.05. (A) On surface righting, only Ts1Cje and Ts65Dn mice show an impairment compared with their euploid littermates. (B) On negative geotaxis, only Ts65Dn mice show a marked impairment compared with their euploid littermates. (C) On forelimb grasp, all trisomic mice perform similarly to their euploid littermates. (D) On cliff aversion, Ts1Cje and Ts65Dn mice show a significant impairment, whereas Dp(16)1/Yey mice show an improvement, compared with their respective euploid littermates. (E) On open field, all trisomic mice perform similarly to their euploid littermates. (F) On eye opening, all trisomic mice perform similarly to their euploid littermates, showing that there was no confound during testing from lack of vision in trisomic mice. (G) On air righting, all trisomic mice show an impairment compared with their euploid littermates. (H) On auditory startle, all trisomic mice show an impairment compared with their euploid littermates. (I) On ear twitch, only Dp(16)1/Yey mice show an impairment compared with euploid littermates.