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. 2018 Jun 25;131(12):jcs213314. doi: 10.1242/jcs.213314

Fig. 4.

Fig. 4.

Hyper-tubulation of the TRE occurs downstream of PIKfyve inhibition. (A) HeLa cells treated with vehicle, FTY720 (10 µM), 893 (10 µM) or C2-ceramide (50 µM) for 1 h or 6 h were stained for MICAL-L1. (B) HeLa cells treated with vehicle, FTY720 (10 µM), 893 (10 µM) or C2-ceramide (50 µM) for 1 h and stained for CD98. (C) HeLa cells treated with PIKfyve inhibitor YM201636 (800 nM) for 1 h and stained for MICAL-L1 or CD98. (D) HeLa cells treated with C2-ceramide (50 µM) or YM201636 (800 nM) alone or in combination for 1 h were stained for MICAL-L1. Scale bars: 10 µm.