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. 2018 Jun 11;145(12):dev159657. doi: 10.1242/dev.159657

Fig. 6.

Fig. 6.

Purmorphamine restores expression of Shh pathway and myogenic genes; however, Gli3 and cell cycle genes remain de-regulated in the absence of miR-133 function. (A-D) RT-qPCR for Shh pathway components (A), myogenic genes (B), cell cycle genes (C) and a regulator of EMT and BMP signalling (D), as indicated. White columns represent somites injected with scrambled antagomir (AMscr), black columns represent somites injected with antagomir-133 (AM133), grey columns represent somites injected with AM133 with purmorphamine. (E) Summary of the regulatory interactions identified in this study. DM, dermomyotome; FP, floor plate; MY, myotome; NC, notochord; NT, neural tube.