Table 1.
Characteristics of women (n=166†) with LMP before 4/1/11 and delivery before 12/31/15, and with antidepressant exposure anytime within 91 days prior to LMP and 32 weeks of gestation. Sample is stratified by pregnancy cumulative dose trajectory membership.
| Trajectory A (n=87) | Trajectory B (n=30) | Trajectory C (n=19) | Trajectory D (n=6) | Pre-pregnancy only (n=24) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | N | % | N | % | |
| Pregnancy and birth outcomes | ||||||||||
| Gestational age at delivery (mean, sd) | 38.2 | 2.1 | 38.3 | 2.0 | 38.0 | 2.2 | 37.7 | 2.7 | 38.5 | 1.6 |
| Preterm birth (<37 weeks gestation) | 12 | 13.8 | 6 | 20.0 | 3 | 15.8 | 1 | 16.7 | 3 | 12.5 |
| Birth weight in grams (mean, sd) | 3271.7 | 612.5 | 3200.6 | 459.6 | 3054.3 | 656.2 | 2947.5 | 391.0 | 3224.1 | 447.2 |
| Low birth weight (<2500g) | 8 | 9.2 | 3 | 10.0 | 4 | 21.1 | 0 | 0.0 | 1 | 4.2 |
| Sociodemographic information | ||||||||||
| Government Insurer | 12 | 13.8 | 1 | 3.3 | 3 | 15.8 | 0 | 0.0 | 4 | 16.7 |
| Smoking during pregnancy | 14 | 16.1 | 5 | 16.7 | 2 | 10.5 | 2 | 33.3 | 1 | 4.2 |
| Non-Hispanic White | 49 | 56.3 | 20 | 66.7 | 13 | 68.4 | 3 | 50.0 | 10 | 41.7 |
| Maternal body mass index prior to LMP‡ (mean, sd) | 26.6 | 7.1 | 25.4 | 4.2 | 26.0 | 5.5 | 26.9 | 4.4 | 25.7 | 5.4 |
| Maternal age at LMP (mean, sd) | 32.0 | 5.0 | 31.1 | 4.3 | 31.8 | 4.8 | 36.5 | 4.2 | 31.6 | 5.6 |
| Antidepressant use | ||||||||||
| SSRI use | 67 | 77.0 | 26 | 87.7 | 16 | 84.2 | 6 | 100.0 | 15 | 62.5 |
| Other antidepressant use | 32 | 36.8 | 9 | 30.0 | 4 | 21.1 | 1 | 16.7 | 14 | 58.3 |
| Potential antidepressant indications | ||||||||||
| Ever diagnosed with depression | 65 | 74.7 | 24 | 80.0 | 18 | 94.7 | 6 | 100.0 | 20 | 83.3 |
| Current depression diagnosis§ | 54 | 62.1 | 21 | 70.0 | 15 | 79.0 | 5 | 83.3 | 12 | 50.0 |
| Current anxiety diagnosis§ | 46 | 52.9 | 18 | 60.0 | 8 | 42.1 | 3 | 50.0 | 9 | 37.5 |
| Current “other mental health” diagnosis§ | 18 | 20.7 | 10 | 33.3 | 3 | 15.8 | 1 | 16.7 | 3 | 12.5 |
| Current migraine diagnosis§ | 20 | 23.0 | 5 | 16.7 | 3 | 15.8 | 1 | 16.7 | 7 | 29.2 |
| Current pain diagnosis§ | 1 | 1.2 | 0 | 0.0 | 1 | 5.6 | 0 | 0.0 | 0 | 0.0 |
| EPDS score¶ (mean, sd) | 8.7 | 6.3 | 8.7 | 7.5 | 6.5 | 4.1 | 6.0 | 3.9 | 5.2 | 3.9 |
| Gestational day of EPDS¶ administration (mean, sd) | 90.1 | 48.4 | 61.3 | 28.5 | 82.0 | 43.6 | 79.8 | 36.9 | 65.7 | 39.1 |
Abbreviations: BMI: body mass index; EPDS: Edinburgh Postnatal Depression Scale; LMP: last menstrual period, SD: standard deviation
166 deliveries includes 5 twin deliveries and 162 unique mothers (4 sibling observations)
n=59/21/19/6/24 with BMI prior to LMP in medical records in clusters A/B/C/D/pre-pregnancy only respectively
Diagnosis at primary care visit between 3 months before the LMP and 3 months after delivery date
EPDS score prior to 32 weeks’ gestation n=75/22/15/6/17 in clusters A/B/C/D/pre-pregnancy only respectively