Table 2.
Multivariable adjusted beta estimates for birth weight and gestational age at delivery according to cumulative and average daily antidepressant use trajectories in weeks 0–32 of pregnancy (n=166).
| Birth weight (in grams) | |||||||
|---|---|---|---|---|---|---|---|
| Cumulative trajectory group | n | Beta estimate | 95% CI | Avg. daily trajectory group | n | Beta estimate | 95% CI |
| Group A1 | 87 | reference | -- | Group A2 | 107 | reference | -- |
| Group B | 30 | −66.5 | −272.4, 139.4 | Group B | 29 | −241.3 | −496.9, 14.2 |
| Group C–D | 25 | −264.8 | −530.5, 0.9 | Group C | 6 | −314.1 | −613.7, −15.5 |
| Pre-pregnancy only | 24 | −50.5 | −279.9, 178.9 | Pre-pregnancy only | 24 | −44.0 | −268.5, 180.5 |
| Gestational age at delivery (in weeks) | |||||||
| Cumulative trajectory group | n | Beta estimate | 95% CI | Avg. daily trajectory group | n | Beta estimate | 95% CI |
| Group A1 | 87 | reference | -- | Group A2 | 107 | reference | -- |
| Group B | 30 | 0.1 | −0.8, 0.9 | Group B | 29 | −0.7 | −1.5, 0.2 |
| Group C-D | 25 | −0.4 | −1.4, 0.6 | Group C | 6 | −0.7 | −2.7, 1.4 |
| Pre-pregnancy only | 24 | 0.2 | −0.6, 1.0 | Pre-pregnancy only | 24 | 0.2 | −0.6, 1.0 |
1
Group A cumulative trajectory mean birth weight was 3271.7 grams, mean gestational age at delivery was 38.2 weeks.
2
Group A average daily trajectory mean birth weight was 3270.6 grams, mean gestational age at delivery was 38.3 weeks.
Models adjusted for EPDS score, gestational day of EPDS administration, maternal age, race, and smoking in pregnancy. CI=confidence interval