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Cortisol competitively inhibits human 3βHSD2 in COS-7 cells. Dixon plot of Cortisol vs. 1/Velocity at DHEA substrate concentrations (μM) of 0.5 (black line), 2 (red line) and 4 (blue line) to obtain Cortisol Ki of 36 μM. Inset: Cortisol (50 μM) addition to DHEA (0.5 μM) increases DHEA substrate (green oval) and decreases androstenedione product (red oval).
