Table 2.
Hemostatic Factors and Odds Ratios of Incident Cognitive Impairment
| Biomarker | Model | Odds Ratio (95% CI) ICI for Categories of Hemostasis Biomarkers | |||
|---|---|---|---|---|---|
| Quartile 2 vs.1 | Quartile 3 vs. 1 | Quartile 4 vs. 1 | Abnormal Value** | ||
| D-dimer, μg/mL | Unadjusted | 1.03 (0.71, 1.52) |
1.51 (1.06, 2.17) |
1.32 (0.92, 1.89) |
1.32 (1.02, 1.70) |
| Adjusted* | 0.94 (0.57, 1.54) |
1.30 (0.80, 2.11) |
1.02 (0.61, 1.71) |
1.17 (0.83, 1.66) |
|
| Fibrinogen, mg/dL | Unadjusted | 1.06 (0.74, 1.54) |
1.09 (0.76, 1.50) |
1.26 (0.8, 1.81) |
1.83 (1.24, 2.71) |
| Adjusted* | 1.24 (0.78, 1.99) |
1.02 (0.65, 1.74) |
0.76 (0.45, 1.27) |
1.40 (0.82, 2.41) |
|
| Factor VIII antigen, % | Unadjusted | 0.71 (0.49, 1.04) |
0.87 (0.60, 1.25) |
1.37 (0.97, 1.93) |
1.63 (1.11, 2.38) |
| Adjusted* | 0.56 (0.34, 0.90) |
0.74 (0.46, 1.20) |
0.94 (0.50, 1.60) |
1.19 (0.71, 1.97) |
|
| Protein C antigen, % | Unadjusted | 0.84 (0.59, 1.19) |
0.97 (0.68, 1.38) |
0.77 (0.52, 1.09) |
1.10 (0.73, 1.65) |
| Adjusted* | 0.78 (0.49, 1.24) |
1.17 (0.73, 1.87) |
0.75 (0.45, 1.24) |
0.94 (0.50, 1.76) |
|
*
Adjusted for age, race, sex, education, income, region, smoking, alcohol use, CAD, atrial fibrillation, hypertension, diabetes, dyslipidemia, LVH, history of TIA, BMI, CRP>90th percentile, aspirin use, statin use, warfarin use, presence of at least 1 Apoe4 allele
**
D-dimer >0.50 μg/mL, factor VIII >90th percentile (168%), fibrinogen >90th percentile (502 mg/dL), protein C <10th percentile (95%)
D-dimer Q1≤0.23 μg/mL, Q2=0.26–0.37 ug-mL, Q3=0.38–0.74 μg/mL, Q4≥0.75μg/mL
Factor VIII Q1≤91%, Q2=91–109%, Q3=109–134%, Q4≥134%
Fibrinogen Q1≤331mg/dL, Q2=332–381 mg/dL, Q3=382–441 mg/dL, Q4≥442 mg/dL,
Protein C Q1≤108%, Q2=108–122%, Q3=122–136%, Q4≥136%