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. 2017 Dec 27;9(4):870–874. doi: 10.1111/jdi.12781

Table 2.

Comparison of change in clinical parameters before and after administration of placebo or empagliflozin

Placebo EMPA P‐value
ΔBW (kg) 0.57 ± 1.28 −3.10 ± 2.02 0.001176*
ΔBMI 0.32 ± 0.61 −1.11 ± 0.94 0.004555*
ΔFBG (mg/dL) −2.6 ± 18.8 −10.9 ± 23.0 0.0448*
ΔHbA1c (%) −0.07 ± 0.37 −0.49 ± 1.1 0.0295*
ΔIRI (μU/mL) 0.17 ± 0.62 −1.06 ± 0.84 < 0.001*
ΔHOMA‐R 0.1 ± 0.437 −0.54 ± 1.11 0.0105*
ΔLDL‐C (mg/dL) 4.13 ± 16.0 2.44 ± 15.8 0.695
ΔHDL‐C (mg/dL) 0.40 ± 6.3 1.4 ± 5.4 0.504
ΔTG (mg/dL) −2.0 ± 30.6 −9.2 ± 47.2 0.486
ΔRLP‐C mg/dL) 0.51 ± 5.5 −0.51 ± 5.5 0.00988*
ΔAST (IU/L) 2.0 ± 5.9 −2.2 ± 9.7 0.0324*
ΔALT (IU/L) 3.4 ± 11 −4.3 ± 13 0.0213*
ΔγGTP (IU/L) 6.0 ± 15 −5.2 ± 17 0.0116*
ΔeGFR (mL/min/1.73 m2) −1.5 ± 7.1 −3.5 ± 6.1 0.00585*
ΔACR (mg/gCr) −0.07 ± 9.6 −12.02 ± 8.4 0.0216*
ΔBNP (pg/mL) 1.6 ± 7.8 −3.2 ± 9.0 0.0421*
ΔhsCRP (mg/L) 0.017 ± 0.16 −0.013 ± 0.83 0.432
ΔSBP (mmHg) −1.7 ± 8.2 −9.2 ± 12 0.0115*
ΔDBP (mmHg) −2.90 ± 6.9 −1.05 ± 10.5 0.409

Data are expressed as mean ± standard deviation. *P < 0.05. γGTP, gamma‐glutamyl transpeptidase; ACR, albumin‐to‐creatinine ratio; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI body mass index; BNP, brain natriuretic peptide; BW, bodyweight; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; EMPA, empagliflozin; FBG, fasting blood glucose; HbA1c, glycated hemoglobin; HDL‐C, high‐density lipoprotein cholesterol; hsCRP, high‐sensitivity C‐reactive protein; LDL‐C, low‐density lipoprotein cholesterol; RLP‐C, remnant‐like particle cholesterol; SBP, systolic blood pressure; TG, triglyceride. (pvalues for intergroup comparison).