Figure 2.
Phenotypes in mutant mice lacking βII spectrin in myelinating glial cells. A, Toe grip strength measurement. Grip strength in each mouse is plotted. N = 7–11 mice in each group. B, Motor nerve conduction velocity in sciatic nerves. Conduction velocity for each mouse is plotted. N = 4–6 mice in each group. Differences of conduction velocity between WT and cKO are shown in 6–24 weeks. Two mice at 2 years of age in each group were available for motor nerve conduction measurements. WT, Sptbn1f/f mice; cHet, Cnp-Cre;Sptbn1f /+ mice; and cKO, Cnp-Cre;Sptbn1f/f mice.