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. 2018 Jun 8;50(2):138–143. doi: 10.3947/ic.2018.50.2.138

Table 1. Summary of cases of breakthrough Trichosporon asahii fungemia in patients with hematologic disease who were receiving antifungal agents (including the present case).

Underlying disease Predisposing condition Site of infection Previous antifungal Tx. Definite Tx. of trichosporonosis Outcome AMB FLC ITC VRC CAF MIF Ref.
Myelodysplastic syndrome SCT Catheter ITC VRC Survived 1 8 16 0.5 16 In this case
AML CTx Primary fungemia CAF L-AMB + VRC Expired >32 4 0.5 >0.015 16 [4]
AML CTx Primary fungemia ITC VRC Survived 1 32 1 0.5 >16 [5]
Thalassemia SCT Catheter FLC VRC Survived 0.25 3 0.04 >32 [9]
AML CTx Catheter FLC AMB + CAF Survived 0.06 >64 [13]
Hematologic malignancy SCT Primary fungemia MIF L-AMB Survived S S S S R R [14]
AML CTx Catheter FLC L-AMB + CAF Survived [15]
AML CTx GI tract PSC VRC + AMB [17]
AML CTx Catheter ITC AMB + FLC Survived [18]
Myelofibrosis CTx Primary fungemia MIF L-AMB Expired [19]
Myelodysplastic syndrome CTx Catheter MIF FLC Expired [20]
AML SCT Primary fungemia MIF FLC Expired [20]
AML CTx Pneumonia AMB + CAF VRC Expired 0.5 8 1 16 [20]
AML CTx Primary fungemia MIF VRC Survived 1 32 1 16 [20]

AMB, amphotericin B deoxycholate; FLC, fluconazole; ITC, itraconazole; VRC, voriconazole; AML, acute myeloid leukemia; CAF, caspofungin; MIF, micafungin; SCT, stem cell transplantation; CTx, chemotherapy; L-AMB, liposomal amphotericin B; PSC, posaconazole.

Blank, not commented in the reference article.