Table 1. Summary of cases of breakthrough Trichosporon asahii fungemia in patients with hematologic disease who were receiving antifungal agents (including the present case).
Underlying disease | Predisposing condition | Site of infection | Previous antifungal Tx. | Definite Tx. of trichosporonosis | Outcome | AMB | FLC | ITC | VRC | CAF | MIF | Ref. |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Myelodysplastic syndrome | SCT | Catheter | ITC | VRC | Survived | 1 | 8 | 16 | 0.5 | 16 | In this case | |
AML | CTx | Primary fungemia | CAF | L-AMB + VRC | Expired | >32 | 4 | 0.5 | >0.015 | 16 | [4] | |
AML | CTx | Primary fungemia | ITC | VRC | Survived | 1 | 32 | 1 | 0.5 | >16 | [5] | |
Thalassemia | SCT | Catheter | FLC | VRC | Survived | 0.25 | 3 | 0.04 | >32 | [9] | ||
AML | CTx | Catheter | FLC | AMB + CAF | Survived | 0.06 | >64 | [13] | ||||
Hematologic malignancy | SCT | Primary fungemia | MIF | L-AMB | Survived | S | S | S | S | R | R | [14] |
AML | CTx | Catheter | FLC | L-AMB + CAF | Survived | [15] | ||||||
AML | CTx | GI tract | PSC | VRC + AMB | [17] | |||||||
AML | CTx | Catheter | ITC | AMB + FLC | Survived | [18] | ||||||
Myelofibrosis | CTx | Primary fungemia | MIF | L-AMB | Expired | [19] | ||||||
Myelodysplastic syndrome | CTx | Catheter | MIF | FLC | Expired | [20] | ||||||
AML | SCT | Primary fungemia | MIF | FLC | Expired | [20] | ||||||
AML | CTx | Pneumonia | AMB + CAF | VRC | Expired | 0.5 | 8 | 1 | 16 | [20] | ||
AML | CTx | Primary fungemia | MIF | VRC | Survived | 1 | 32 | 1 | 16 | [20] |
AMB, amphotericin B deoxycholate; FLC, fluconazole; ITC, itraconazole; VRC, voriconazole; AML, acute myeloid leukemia; CAF, caspofungin; MIF, micafungin; SCT, stem cell transplantation; CTx, chemotherapy; L-AMB, liposomal amphotericin B; PSC, posaconazole.
Blank, not commented in the reference article.