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. 2018 Jul 4;8:10143. doi: 10.1038/s41598-018-28530-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Parameters for assessing the foveal avascular zone (FAZ) obtained by optical coherence tomorgraphy angiography (OCTA). (A) The FAZ area was measured manually with the imageJ software. (B) Area (A₁) and length of perimeter (P) was calculated automatically. Circularity was calculated as 4π × A₁/P². (C) Ellipse was semi-automatically fitted to the FAZ by imageJ. (D) The major axis (L_major) and minor axis (L_minor) lengths were automatically calculated. The axial ratio was calculated as L_major/L_minor. Roundness was calculated as 4π × A₁/(L_major)². (E) The convex hull was semi-automatically fit by imageJ. (F) Area of convex square(A₂) was automatically calculated. Solidity was calculated as A1/A2.