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. 2018 Jul 4;8:10091. doi: 10.1038/s41598-018-28375-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The behaviours of degree distributions (P(k)), clustering co-efficient (C(k)), neighborhood connectivity (C_N(k)), betweenness (C_B(k)), closeness (C_C(k)) and eigen-vector (C_E(k)) measurements as a function of degree k for original and BDNF knockout network at different levels of organization. (B) The changes in the exponents of the six topological parameters due to BDNF knock-out experiment. (C) Changes in the Energy distribution in the network quantified by Hamiltonian calculation as a function of network levels in original and BDNF knockout network.