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. 2018 Jul 4;8:10090. doi: 10.1038/s41598-018-28480-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Characteristics of Patient A and his family. (a) Pedigree of the Patient A in this study. The letter ‘P’ indicates a proband (Patient A, I-1) of this family. The patients are represented by DIO2 activity and thyroid disease state. The results of DIO2 and TSHR genotypes of the patients and their thyroid functions in this family are also presented. (b) Serial thyroid function tests and thyroid hormone dosages of the proband (I-1) are presented. Note that TSH is suppressed only after L-T3 is administered and thyroid function is maintained normal range with combination of L-T4 and L-T3.