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. 2018 Jul 4;8:10082. doi: 10.1038/s41598-018-28414-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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qRT-PCR validation of DGE results of polysaccharides on the genes in T and B cells in immunosuppressed mice. (A) The expression of B cell genes. The figure shows that the polysaccharide formula could up-regulate Fcgr3, Cadm1, Ccr2, Ligp1, C1qa, IgllI, Ly6a, Ubd and Fcgr2 in B cells, consistent with the results of DGE. (B) The expression of T cell genes. The figure shows that t the polysaccharide formula could up-regulate S100a9, S100a8, Chil3, Slfn4, and Ifim3 in T cells, consistent with the results of DGE. (*p < 0.05, **p < 0.01).