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. 2018 Jul 4;8:10105. doi: 10.1038/s41598-018-28366-1

Figure 5.

Figure 5

miRNA expression analysis in control and ALS iPSCs and ATF3 quantification after enoxacin treatment. (a) qPCR experiments performed on miR-34a, miR-504, miR-367 and miR-302b in control (CTRL) and ALS iPSCs (ALS) treated or not treated with 100 μM enoxacin for 48 hours. Enoxacin treatment increased the amount of miRNAs in both control and ALS iPSCs (***P < 0.0001 and **P < 0.01, student t-test, values represent means + SEM). The experiment was repeated three times. (b) qPCR experiments performed on ATF3 in control (CTRL) and ALS-MN progenitors (ALS) treated or not treated with 100 μM enoxacin for 48 hours. ALS displayed significant low levels of ATF3 (**P < 0.01, student t-test, values represent means + SEM).