Table 2.

Associations of CTLA-4 49 G/A With Quantitative Traits in 1280 Glucose-Tolerant East Chinese Individuals.

	AA	GA	GG	β	SE	P	adjusted P
n (men/women)	128(45/83)	568(166/402)	579(186/393)
Age (years)	55.9 ± 9.4	56.0 ± 9.5	55.6 ± 9.0
BMI (kg/m2)	23.8 ± 5.5	23.4 ± 3.0	23.3 ± 3.2	0.176	0.146	0.228
Plasma glucose (mmol/l)
Fasting	5.3 ± 0.3	5.3 ± 0.3	5.3 ± 0.4	−0	0.015	0.999	0.807
30 min post OGTT	8.6 ± 1.6	8.6 ± 1.4	8.8 ± 1.5	−0.12	0.062	0.092	0.055
120 min post OGTT	6.2 ± 0.9	6.1 ± 1.0	6.2 ± 1.0	−0.04	0.04	0.472	0.287
Serum insulin (mIU/l)
Fasting	9.23(7.33–13.45)	10.12(7.25–14.00)	9.72(7.33–13.61)	0	0.01	0.806	0.967
30 min post OGTT	52.59(38.11–80.91)	59.70(40.59–95.21)	56.39(36.53–87.34)	0	0.013	0.807	0.977
120 min post OGTT	42.23(25.79–71.12)	39.80(25.04–67.00)	43.15(28.58–65.87)	−0.01	0.013	0.701	0.473
islet function
HOMA-β	107.23(80.42–148.39)	111.77(80.13–160.77)	104.97(80.83–154.93)	−0	0.011	0.958	0.953
IGI	13.86(9.10–22.42)	15.70(9.07–26.87)	14.54(7.69–23.60)	0.025	0.017	0.108	0.151
BIGTT-AIR	1864.9(1458.7–2619.9)	2067.4(1490.8–3041.1)	1903.1(1427.1–2782.6)	0.003	0.014	0.823	0.84
CIR	144.77(90.66–217.29)	161.68(95.22–256.91)	141.62(85.79–227.11)	0.015	0.015	0.287	0.33
insulin resistance
HOMA-IR	2.18(1.70–3.22)	2.39(1.70–3.33)	2.31(1.72–3.27)	0.001	0.01	0.771	0.951
ISIc	0.072(0.038–0.134)	0.066(0.041–0.112)	0.068(0.042–0.109)	0.007	0.014	0.905	0.603
BIGTT-SI	1.7 ± 0.7	1.8 ± 0.7	1.8 ± 0.7	−0.01	0.03	0.819	0.831
disposition indexes (DI)
DI 1	13719(9406–17982)	14463(10376–19329)	13312(9764–17872)	0	0.014	0.987	0.993
DI 2	62.00(40.69–92.88)	64.74(41.25–108.93)	59.79(34.63–102.58)	0.014	0.016	0.434	0.404

Note: IGI, the insulinogenic index; ISIc, Matsuda’s insulin sensitivity index; DI 1, BIGTT-AIR*BIGTT-SI; DI 2, CIR/HOMA-IR.