Table 3.
Antibody association for CTLA-4 +49 G/A in T1D patients
| Pos | Neg | OR (95% CI) | P value | |
|---|---|---|---|---|
| ZnT8A | ||||
| A | 225 | 298 | 0.84 [0.68, 1.03] | 0.09 |
| GG | 249 | 259 | 1 | — |
| GA | 167 | 220 | 0.79 [0.61, 1.03] | 0.08 |
| AA | 29 | 39 | 0.77 [0.46, 1.29] | 0.32 |
| GADA | ||||
| A | 372 | 184 | 0.89 [0.72, 1.09] | 0.26 |
| GG | 379 | 156 | 1 | — |
| GA | 268 | 138 | 0.80 [0.61, 1.05] | 0.11 |
| AA | 52 | 23 | 0.93 [0.55, 1.57] | 0.79 |
| IA-2A | ||||
| A | 235 | 319 | 0.78 [0.64, 0.95] | 0.01** |
| GG | 266 | 269 | 1 | — |
| GA | 185 | 219 | 0.85 [0.66, 1.11] | 0.23 |
| AA | 25 | 50 | 0.51 [0.30, 0.84] | 0.008** |
| IAA | ||||
| A | 60 | 175 | 0.93 [0.66, 1.31] | 0.69 |
| GG | 63 | 172 | 1 | — |
| GA | 48 | 129 | 1.02 [0.65, 1.58] | 0.94 |
| AA | 6 | 23 | 0.71 [0.28, 1.83] | 0.48 |
Note: For each autoantibody, the first row indicates the minor allele for which the odds ratio (OR) is estimated (95% confidence intervals (CI) is shown between brackets. For the genotypic association the most common homozygous group was taken as the reference. The association tests include age at T1D onset and duration as covariates. Numbers in parenthesis indicate the frequency of this genotype or allele. Pos, positive; Neg, negative; **P < 0.01.