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. 2018 Jul 4;8:10134. doi: 10.1038/s41598-018-27740-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Interaction network and miRNA target prediction analysis of down- and upregulated miRNAs (A) showing the central role of Adrb2, Cask (B) and Ppp3r1 (C) mRNAs. High-resolution network is available as an online Supplementary material (Supplementary Fig. 1). Downregulated, upregulated miRNAs and mRNAs are indicated in green, red and blue, respectively. Dark blue represents mRNAs with at least 4 target interactions. Venn diagram presenting the number of predicted up- and downregulated miRNA targets (D).