Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 4;8:10138. doi: 10.1038/s41598-018-28356-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Sexually dimorphic methylation differences on the X chromosome are observed beyond CpG island boundaries. (A) Metaplots of CpG methylation level at CpG islands overlapping exactly one TSS on chromosome X (n = 275) and chromosome 3 (n = 429) for C3 animals (Red, female; Blue, male). CpG islands are oriented to the direction of transcription of the overlapped TSS, and the upstream and downstream CpG island edges are independently scaled relative to the TSS. An additional 3 kb to either side of the CpG island (unscaled) is included. (B) Smoothed kernel density scatterplots comparing male and female single-site methylation levels on chromosomes X and 3, by proximity to CpG islands. C3 female mCG/CG (y-axis) versus C3 male mCG/CG (x-axis) is plotted for CpG sites with depth of at least 10x in each sample located in CpG islands, within 0–2 kb from a CpG island edge, within 2–4 kb from a CpG island edge, or greater than 4 kb from the nearest CpG island. Points to the upper-left of the diagonal reflect CpGs with greater female methylation and points to the lower-right of the diagonal reflect CpGs with greater male methylation. Number of CpGs included on the X chromosome: CpG island, 39,050; <2 kb, 24,571; 2–4 kb, 18,336; >4 kb, 680,325. Number of CpGs included on chromosome 3: CpG island, 56,661; <2 kb, 31,576; 2–4 kb, 27,092; >4 kb, 883,370. Density color keys are shown to the right of each plot. ChrX, chromosome X; Chr3, chromosome 3.