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. 2018 Jul 4;9:2607. doi: 10.1038/s41467-018-05061-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — NP characterization. a A schematic diagram of a core-shell PLGA-lipid NP. b Cryo-TEM images of a Lip-F127_5% NP (left), a PLGA₇₀-Lip-F127_5% NP (middle), and a PLGA₁₆₀-Lip-F127_5% NP (right). Scale bar: 100 nm. c Peak fluorescence intensity and d Young’s modulus values of NPs with different hydrodynamic diameters of PLGA core. (n = 3). e Atomic force microscopy (AFM) images of Lip-F127_5% NPs, PLGA₇₀-Lip-F127_5% NPs, and PLGA₁₆₀-Lip-F127_5% NPs and the corresponding deformation images of the NPs after being subjected to forces of different magnitudes. Scale bar: 200 nm