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Role of guanylyl cyclase and cGMP in RCE-induced relaxation. (A) Endothelium-intact aortic rings were subjected to cumulative doses of sumac without (circles; RCE) or with pre-incubation with ODQ (1 μM; squares; ODQ + RCE). Data represent mean ± SEM (n = 7; p < 0.01 for RCE versus ODQ + RCE). (B) Accumulation of cGMP in aortic rings in the absence or presence of increasing doses of RCE. Each bar represents mean ± SEM (∗p < 0.05, ∗∗p < 0.001, and ∗∗∗p < 0.0001).
