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. 2018 Jun 28;9:688. doi: 10.3389/fphar.2018.00688

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Copyright © 2018 Anwar, Samaha, Baydoun, Iratni and Eid.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of experimental data of Rhus coriaria (sumac)-evoked signaling in aortic relaxation. The diagram illustrates guanylyl cyclase’s (royal blue color) role as a nexus between the proximal activators and distal effectors, and also incorporating the activation of adenylyl cyclase system (purple). Additional contributory routes are implicated by red dashed arrows (convergence hubs for cross-talk between the two systems). Light blue boxes are antagonists. RCE, Rhus coriaria extract; AC, adenylyl cyclase; EPAC, exchange protein directly activated by cAMP; NO, nitric oxide; eNOS, endothelial nitric oxide synthase. Please see text for details. Solid lines in the figure are either established in this study or already published.