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Molecular structures of orexin precursor and orexins. (A) Genomic DNA of human prepro-orexin containing two exons and one intron. (B) The mRNA of human orexin, including the 5’ untranslated region (UTR), signal peptide, open reading frame (ORF) encoding orexin-A (OA) or orexin-B (OB), and 3’ UTR. (C) Amino acid sequences of OA (33 aa) and OB (28 aa). Green labels indicate amino acids that are identical in both OA and OB.
