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Schematic diagram illustrating the roles of orexin/receptor in ethanol seeking. Administration of OA or OB into the PVN, LH and aPVT induces ethanol seeking. In accordance with these findings, intraperitoneal administration of OX1R or OX2R antagonist decreases ethanol intake and ethanol self-administration. Abbreviation: PVN, paraventricular nucleus; LH, lateral hypothalamus; aPVT, anterior paraventricular thalamus; NAc, nucleus accumbens; VTA, ventral tegmental area.
