Table 2.
Significant Prognostic Factors for Overall Survival and PFS
| Overall Survival | Progression Free Survival | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median | SE | 95%CI | Log rank | P value | Median | SE | 95%CI | Log rank | P value | |
| Disease volume | ||||||||||
| Low | 49 | 7.8 | 33.8-64.2 | 9.6 | 0.002 | 48 | 8.4 | 31.6 – 64.4 | 21 | <0.001 |
| High | 27 | 4.7 | 17.8-36.2 | 19 | 2.9 | 13.4 – 24.6 | ||||
| PSA range | ||||||||||
| < 20 | --- | --- | ----- | 13.3 | 0.004 | 36 | 8.7 | 19-53 | 29.3 | <0.001 |
| 20 – 100 | 38 | 2.8 | 32.6-43.4 | 35 | 4.2 | 26.8-43.2 | ||||
| 100 – 1,000 | 49 | 14.3 | 21-77 | 21 | 7.3 | 6.8-35.2 | ||||
| > 1,000 | 15 | 7.6 | 0.04-30 | 6 | 1.8 | 2.5-9.5 | ||||
| Metastatic sites | ||||||||||
| Bone only | 40 | 5.1 | 30.1-49.9 | 9.4 | 0.002 | 36 | 2.6 | 30.8-41.2 | 19.1 | <0.001 |
| bone and | 24 | 3.4 | 17.3-30.7 | 12 | 1.9 | 8.2-15.8 | ||||
| Soft tissue | 19 | 5.6 | 8.0-30 | |||||||
| Visceral metastases | 36 | 3.5 | 29.1-42.9 | 17.8 | <0.001 | |||||
| present | 39 | 5.7 | 27.8-50.2 | 8.7 | 0.003 | 12 | 2 | 8.1-15.9 | ||
| absent | 24 | 5.6 | 12.9-35.1 | |||||||
| Bony metastases | ||||||||||
| No and Scanty | 40 | 1.9 | 36.3-43.7 | 7.4 | 0.007 | ---- | --- | ----- | 17.7 | <0.001 |
| Extensive | 24 | 6.8 | 10.7-37.3 | 41.1 | 4.2 | 27.7-44.3 | ||||
| 25.1 | 4.6 | 7.0-25.0 | ||||||||
| Skeletal related event | ||||||||||
| absent | 52 | 7.9 | 37.8-65.7 | 7.5 | 0.006 | 48 | 3.5 | 21-64.3 | 21.8 | <0.001 |
| present | 32 | 5.4 | 25.6-43.8 | 19 | 4.2 | 10.9-27.1 | ||||