Table 2.

Differentially Expressed Oxidative Stress-related Genes in Oral Squamous Cell Carcinoma

Gene Symbol	Gene Name	Chromosome	Gene ID	Fold change (median)	Minimum	Maximum	P-value
ALOX12*	Arachidonate 12-lipoxygenase,12S type	17p13.1	239	0.029	0.0007	0.223	0.015
ATOX1	Antioxidant 1copper chaperone	5q32	475	1.555	0.904	5.086	0.031
CAT	Catalase	11p13	847	0.639	0.184	1.111	0.009
CSDE1*	Cold shock domain containing E1	1p22	7812	0.769	0.336	1.252	0.043
DHCR24*	24-dehydrocholesterol reductase	1p32.3	1718	0.393	0.140	1.097	0.031
DUOX1*	Dual oxidase 1	15q15.3	53905	0.160	0.065	0.645	0.031
DUOX2*	Dual oxidase 2	15q15.3	50506	0.254	0.086	0.907	0.031
EPHX2*	Epoxidehidrolase 2	8p21	2053	0.167	0.043	0.417	0.031
GLRX2*	Glutaredoxin 2	1q31.2	51022	0.663	0.348	0.790	0.031
GPX3*	Glutathione peroxidase 3 (plasma)	5q33.1	2878	0.318	0.021	0.913	0.015
GSR*	Glutathione-disulfide reductase	8p21.1	2936	0.599	0.125	0.937	0.006
GSTZ1*	Glutathiona S-transferase zeta 1	14q24.3	2954	0.693	0.500	0.921	0.031
MGST3*	Microsomal glutathione S-transferase 3	1q23	4259	0.533	0.364	1.234	0.031
OXR1*	Oxidation Resistance 1	8q23	55074	0.411	0.151	0.982	0.031
OXSR1*	Oxidative-stress responsive 1	3p22.2	9943	0.643	0.206	0.942	0.015
PRDX1	Peroxiredoxin 1	1p34.1	5052	0.511	0.134	1.064	0.001
PRDX4	Peroxiredoxin 4	Xp22.11	10549	1.610	1.169	3.385	0.031
PRNP	Prion protein	20p13	102460857	2.74	0.961	4.823	0.031
SOD1*	Superoxide dismutase 1, soluble	21q22.11	6647	0.528	0.226	0.977	0.008
SOD2	Superoxide dismutase 2, mitochondrial	6q25.3	6648	1.79	0.571	3.151	0.022
SOD3	Superoxidedismutase 3, extracellular	4p15.2	6649	0.178	0.055	0.948	0.031

^*Biomarkers not yet evaluated in oral squamous cell carcinoma. Fold change > 1 – overexpressed genes. Fold change < 1 – down-expressed genes.