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3D protein structure model of ETF-QO based on the crystal structure of porcine ETF-QO reported by Zhang and colleagues [10]. a) ETF-QO is modeled in complex with FAD (green), 4Fe4S (magenta) and UQ (red). The four variants are shown as cyan spheres. b-e) Magnified images of b) R175 and variant H175, c) G77 and variant S77, d) G386 and variant D386, and e) W484 and variant R484. W484 forms hydrophobic interactions with Y470 and F474, while R484 does not.
