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. 2018 Jun 15;175(15):3175–3183. doi: 10.1111/bph.14361

Figure 3.

Figure 3

PRMT3 inhibition decreases hepatic expression of LXR target genes involved in lipogenesis. (A) Schematic summary of the LXR‐regulated lipogenic processes involving ACC, FAS and SCD‐1. SFA, saturated fatty acids; MUFA, monounsaturated fatty acids. (B) PRMT3 inhibition with SGC707 results in decreased hepatic expression of SREBP1c, ACC, FAS and SCD‐1. (C) There is a highly significant positive correlation for ACC versus FAS, ACC versus SCD‐1 and FAS versus SCD‐1. (D and E) The effects of SC707 on lipogenic genes are not caused by an effect on gene expression of LXRα or PRMT3. T09 + PO, T0901317 and palm oil. DMSO, n = 6; T09 + PO, n = 7; T09 + PO + SGC707, n = 9. Data represent mean ± SEM. $Significant as compared with T09 + PO group; *significant as compared with DMSO group.