Skip to main content
. 2018 Jun 15;175(15):3111–3130. doi: 10.1111/bph.14352

Figure 8.

Figure 8

Schematic diagram illustrating the mechanism for the anticancer effect of PEP06. PEP06 exerts anti‐metastasis effects in CRC via inhibiting EMT and increases mouse survival times. This was possibly mediated by the ability of PEP06 to inhibit miR‐146b‐5p, indicating an important role of miR‐146b‐5p in the regulation of Smad4 and TGFβ.