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. 2018 Jan 17;314(5):F969–F984. doi: 10.1152/ajprenal.00551.2017

Fig. 9.

Fig. 9.

Schematic diagram summarizing predicted effects, and the underlying mechanisms, of acute and chronic SGLT2 inhibition on a nondiabetic kidney (A) and a diabetic kidney (B) in terms of urinary excretion of glucose (UG), Na+ (UNa), K+ (UK), and fluid (UV). Arrows in pink boxes indicate effects of acute/chronic SGLT2 inhibition in a nondiabetic/diabetic kidney. Arrows in green boxes indicate the effects of nephron loss in a nondiabetic/diabetic kidney treated with SGLT2 inhibition. Arrow size scales with effect. Blood G, blood glucose.