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. 2018 Jan 31;314(5):F999–F1007. doi: 10.1152/ajprenal.00177.2017

Fig. 5.

Fig. 5.

High NaCl loading stimulates NCC activity in both WT and Wnk4-KO mice. A: HCTZ-induced Na+ excretion in WT mice under control or NaCl loading (0.5 ml normal saline per 25 g body wt via subcutaneous injection, twice a day for 3 consecutive days). n = 8 each. B: urinary K+ excretion in WT and Wnk4-KO mice that received no (control) or subcutaneous injection of NaCl. Number inside bars indicates number of mice for each condition. C: serum K+ levels of mice from experiments in B. D: HCTZ-induced Na+ excretion in Wnk4-KO mice under control or NaCl loading. n = 5 each. E: HCTZ-sensitive Na+ excretion rate (0–4 h post-HCTZ administration minus Pre-HCTZ) in WT and Wnk4-KO mice under control or NaCl loading. *P < 0.05 NaCl vs. control for respective strain. #P < 0.05, Wnk4-KO vs. WT. F: Na+ excretion rate 0–4 h post-amiloride administration and pre-amiloride in WT mice under control or NaCl loading. *P < 0.05 Post vs. Pre for respective condition. #P < 0.05 between indicated. Open bar (labeled “∆”) indicates amiloride-sensitive Na+ excretion rate (0–4 h post-administration minus Pre).