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Effect of inhibition of Toll-like receptor-4 (TLR4) signaling on renal blood flow following the intravenous administration of hemin. With the use of a perivascular flow probe, blood flow rate in the renal artery was measured for 30 min after the administration of hemin (32 μmol/kg iv) with pretreatment with the TLR4 signaling inhibitor TAK-242 (2 mg/kg ip) or vehicle; n = 4 in each group. *P < 0.05 vs. vehicle treatment at that time point.
