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Effect of inhibition of TLR4 signaling on renal function in mice subjected to the glycerol model of heme protein-mediated injury. Plasma levels of creatinine (A) and blood urea nitrgoen (BUN; B) in mice 1 and 2 days after the induction of the glycerol model with treatment with the TLR4 signaling inhibitor TAK-242 or vehicle; n = 5 in each saline-treated control group and n = 8 in each group subjected to the glycerol model.
